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修饰性PEG的用途
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1、蛋白质类药物PEG修饰： PEG修饰蛋白质药物可以延长药物的半衰期、降低免疫原性，同时限度地保留其生物活性。作为治疗药物，经过聚乙二醇(PEG)修饰的蛋白质比未修饰的蛋白质更有效。PEG对蛋白药物修饰途径主要有氨基修饰（包括N端氨基的酰化修饰、赖氨酸侧链氨基的酰化修饰、N端氨基的烷基化修饰）、羧基修饰、巯基修饰等。目前，国内外对PEG修饰蛋白质类药物的研究主要集中于腺苷脱氨酶、天冬酰胺酶、干扰素、粒细胞集落刺激因子、白细胞介素等，更有40多个药物正在进行临床研究。
2、肽类化合物PEG修饰：肽类化合物PEG修饰，如畦降钙素、表皮生长因子的PEG修饰产物的半衰期和生物活性显著高于原型药物。尤其是肽类化合物在聚乙二醇定点修饰方面较蛋白质更易于实现。在肽类化合物的PEG修饰研究中应用普遍的是mPE
3、PEG修饰脂质体：普通免疫脂质体由于在血液中的循环半衰期短，易于被清除，限制了其发展。PEG修饰的长循环脂质体，增加了脂质体的血液循环时间，不但能够逃避网状内皮系统的捕获，还能提高脂质体的被动靶向性。已经被广泛用于脂质体药物制剂。
4、PEG修饰小分子药物：很多小分子药物，目前以抗药物为多，采用PEG修饰技术，聚乙二醇支载小分子，可以把它的许多优良性质也随之转移到结合物中，使该聚合物具有优异的生物相容性，在体内能溶于组织液中，能被机体迅速排出体外而不产生任何毒副作用。很多抗药物通过高分子量PEG修饰，能够达到组织的被动靶向给药。
5、其它应用：PEG修饰亲和配体和辅因子在含水的两相分配系统中应用，用于生物大分子和细胞的纯化和分析。PEG修饰糖类可作为新的药物材料、药物载体。寡核苷酸PEG化可以增加溶解度，增加对核酸酶的抵抗和细胞膜穿透性。生物材料PEG化可以减少形成，降低蛋白质和细胞黏附性。
常规产品
|
货号
|
产品
|
分子量
|
规格
|
|
MPEG-ACRL
|
mPEG-Acrylate
|
5000
|
1 gram;
5 gram |
|
ACRL-PEG-ACRL
|
Acrylate-PEG-Acrylate
|
3400; 5000; 10K; 20K
|
1 gram;
5 gram |
|
ACRL-PEG-SVA
|
Acrylate-PEG-SVA
|
3400
|
500 mg;
1 gram; 5 gram |
|
4arm-PEG-ACRL
|
4arm-PEG-ACRL
|
10K
|
1 gram;
5 gram |
|
ACRL-PEG-ACRL-4MW Kit
|
Acrylate-PEG-Acrylate, 4 MW Kit
|
Kit
|
|
|
MPEG-bALD
|
mPEG-Butyraldehyde
|
2K; 5K; 10K; 20K; 30K
|
1 gram;
5 gram |
|
bALD-PEG-bALD
|
ButyrAldehyde-PEG-ButyrAldehyde
|
3400
|
1 gram;
5 gram |
|
bALD-PEG-SVA
|
ButyrAldehyde-PEG-SVA
|
3400
|
1 gram
|
|
MPEG-bALD-4MW Kit
|
mPEG-Butyraldehyde, 4MW Kit
|
Kit
|
|
|
MPEG-NH2
|
mPEG-Amine
|
2000; 5000; 10K; 20K; 30K
|
1 gram;
5 gram |
|
NH2-PEG-NH2
|
Amine-PEG-Amine
|
2K; 3400; 5K; 10K; 20K
|
1 gram
|
|
NH2-PEG-SH
|
NH2-PEG-Thiol
|
3400; 5000
|
1 gram;
500 mg |
|
NH2-PEG-VA
|
Amine-PEG-Valeric Acid
|
3400; 5K
|
1 gram;
500mg |
|
Biotin-PEG-NH2
|
Biotin-PEG-NH2
|
3400
|
1 gram;
100 mg |
|
DSPE-PEG-NH2
|
DSPE-PEG-NH2
|
3400
|
500 mg;
1 gram; 5 gram |
|
HO-PEG-NH2
|
HO-PEG-NH2
|
3400
|
500 mg;
1 gram; 5 gram |
|
BOC-NH-PEG-NH2
|
BOC-NH-PEG-Amine
|
3400
|
500 mg;
1 gram; 5 gram |
|
联系电话：18018625233(同微信) QQ:2303607288
|
|||
|
MPEG-Biotin
|
mPEG-Biotin
|
2000;5000;10K;20K
|
1 gram;
5 gram |
|
Biotin-PEG-DSPE
|
Biotin-PEG-DSPE
|
3400
|
1 gram;
500 mg |
|
Biotin-PEG-MAL
|
Biotin-PEG-Maleimide
|
3400
|
500 mg;
1 gram; 100 mg |
|
Biotin-PEG-SIL
|
Biotin-PEG-Silane
|
3400
|
1 gram;
500 mg |
|
Biotin-PEG-SC
|
Biotin-PEG-SC
|
3400;5000
|
500 mg;
1 gram; 100 mg |
|
Biotin-PEG-SVA
|
Biotin-PEG-SVA
|
3400;5000
|
100 mg;
500 mg; 1 gram |
|
MPEG-Biotin-4MW Kit
|
mPEG-Biotin, 4MW Kit
|
Kit
|
|
|
ASA-PEG-ASA
|
Amino Succinic Acid-PEG-Amino Succinic Acid
|
3400
|
1 gram
|
|
CM-PEG-SH
|
Carboxymethyl-PEG-Thiol
|
3400;5000
|
500 mg;
1 gram; 5 gram |
|
HO-PEG-CM
|
HO-PEG-CM
|
3400
|
500 mg;
1 gram; 5 gram |
|
4arm-PEG-ASA
|
4arm-PEG-ASA
|
10K
|
1 gram
|
|
mPEG-SAS
|
mPEG-Succinimidyl Amido Succinate
|
2K;5K
|
1 gram;
5 gram |
|
MPEG-SAS
|
mPEG-Succinimidyl Amido Succinate
|
10K;20K
|
1 gram;
5 gram |
|
mPEG-SC
|
mPEG-Succinimidyl Carbonate
|
2K
|
1 gram;
5 gram |
|
MPEG-SC
|
mPEG-Succinimidyl Carbonate
|
5000;10K;20K
|
1 gram;
5 gram |
|
MPEG-SG
|
mPEG-Succinimidyl Glutarate
|
5000
|
1 gram;
5 gram |
|
MPEG-SS
|
mPEG-Succinimidyl Succinate
|
2000;5000;10K;20K
|
1 gram;
5 gram |
|
MPEG-SVA
|
mPEG-Succinimidyl Valerate
|
2000;5000;10K;20K;30K
|
1 gram;
5 gram |
|
联系电话：18018625233(同微信) QQ:2303607288
|
|||
|
SAS-PEG-SAS
|
SAS-PEG-SAS
|
3400
|
1 gram;
5 gram |
|
SG-PEG-SG
|
SG-PEG-SG
|
3400
|
1 gram;
5 gram |
|
SS-PEG-SS
|
SS-PEG-SS
|
3400
|
1 gram;
5 gram |
|
SVA-PEG-SVA
|
SVA-PEG-SVA
|
3400
|
1 gram;
5 gram |
|
BOC-NH-PEG-SC
|
BOC-NH-PEG-SC
|
3400
|
500 mg;
1 gram; 5 gram |
|
BOC-NH-PEG-SVA
|
BOC-NH-PEG-SVA
|
3400
|
500 mg;
1 gram; 5 gram |
|
FMOC-NH-PEG-SVA
|
FMOC-NH-PEG-SVA
|
500 mg;
1 gram; 5 gram |
|
|
MAL-PEG-SVA-3400ram
|
Maleimide-PEG-Succinimidyl Valerate
|
500 mg;
1 gram; 5 gram |
|
|
OPSS-PEG-SVA
|
OPSS-PEG-SVA
|
5000
|
1 gram;
500 mg |
|
4arm-PEG-SAS
|
4arm-PEG-SAS
|
10K
|
1 gram
|
|
4arm-PEG-SC
|
4arm-PEG-SC
|
10K
|
1 gram
|
|
4arm-PEG-SG
|
4arm-PEG-SG
|
10K
|
1 gram;
5 gram |
|
4arm-PEG-SS
|
4arm-PEG-SS
|
10K
|
1 gram;
5 gram |
|
联系电话：18018625233(同微信) QQ:2303607288
|
|||
|
NH2-Reactive Kit 5K
|
Amine Reactive Kit
|
Kit
|
|
|
MPEG-SAS 4 MW Kit
|
mPEG-Succinimidyl Amido Succinate, 4 MW Kit
|
Kit
|
|
|
MPEG-SC 4 MW Kit
|
mPEG-Succinimidyl Carbonate, 4 MW Kit
|
Kit
|
|
|
MPEG-SS 4 MW Kit
|
mPEG-Succinimidyl Succinate, 4 MW Kit
|
Kit
|
|
|
HO-PEG-MAL
|
HO-PEG-MAL
|
3400;5000
|
500 mg;
1 gram; 5 gram |
|
HO-PEG-VA
|
HO-PEG-VA
|
3400
|
500 mg;
1 gram; 5 gram |
|
FMOC-NH-PEG-OH
|
FMOC-NH-PEG-OH
|
5000
|
1 gram;
5 gram |
|
HO-PEG-NH2
|
HO-PEG-NH2, MW 1,000
|
1000;2000;5000;20K;35K
|
500 mg;
1 gram |
|
HO-PEG-CM
|
HO-PEG-CM
|
2000;5000
|
500 mg;
1 gram |
|
HO-PEG-MAL
|
HO-PEG-MAL
|
2000
|
500 mg;
1 gram |
|
SH-Reactive Kit 5K
|
Thiol Reactive Kit
|
Kit
|
|
|
NH2-PEG-NH2-5MW-Kit
|
Amine-PEG-Amine, 5 MW Kit
|
Kit
|
|
|
CM-PEG-SH-3MW Kit
|
CM-PEG-SH, 3MW Kit
|
Kit
|
|
|
MPEG-NH2-4MW Kit
|
mPEG-Amine, 4MW Kit
|
Kit
|
|
|
MPEG-Biotin-4MW Kit
|
mPEG-Biotin, 4MW Kit
|
Kit
|
|
|
MPEG-MAL-4MW Kit
|
mPEG-Maleimide, 4MW Kit
|
Kit
|
|
|
MPEG-NPC 4 MW Kit
|
mPEG-Nitrophenyl Carbonate, 4 MW Kit
|
Kit
|
|
|
MPEG-SH-4MW Kit
|
mPEG-Thiol, 4 MW Kit
|
Kit
|
|
上海惠诚生物科技有限公司 “惠质产品，挚诚服务”。
上海惠诚生物特色产品：糖类标准品，脂肪酸标准品，花青素标准品，类胡萝卜素,人乳寡糖等食品分析标准品
联系电话：18018625233(同微信) QQ:2303607288
mPEG-MAL
|
mPEG-Maleimide
|
2000
|
1 gram
|
|
|
MPEG-MAL
|
mPEG-Maleimide
|
5000;10K;20K;30K
|
1 gram;
5 gram |
|
MAL-PEG-MAL
|
Maleimide-PEG-Maleimide
|
3400
|
1 gram;
5 gram |
|
DSPE-PEG-MAL
|
DSPE-PEG-Maleimide
|
3400
|
500 mg;
1 gram; 5 gram |
|
MAL-PEG-SVA
|
Maleimide-PEG-Succinimidyl Valerate
|
5000
|
100 mg
500 mg |
|
4arm-PEG-MAL
|
4arm-PEG-MAL
|
10K
|
1 gram;
5 gram |
|
4arm-PEG-NH2
|
4arm-PEG-NH2
|
10K
|
1 gram;
5 gram |
|
4arm-PEG-SH
|
4arm-PEG-Thiol
|
10K
|
1 gram;
5 gram |
|
mPEG-NPC
|
mPEG-Nitrophenyl Carbonate
|
2000;5000;10K;20K
|
1 gram;
5 gram |
|
NPC-PEG-NPC
|
NPC-PEG-NPC
|
3400
|
1 gram;
5 gram |
|
MPEG-OPSS
|
mPEG-Orthopyridyl Disulfide
|
5000
|
1 gram;
5 gram |
|
OPSS-PEG-SVA
|
OPSS-PEG-SVA
|
3400
|
500 mg;
1 gram |
|
MPEG-DSPE
|
mPEG-DSPE
|
5000
|
1 gram;
5 gram |
|
BOC-NH-PEG-SVA
|
BOC-NH-PEG-SVA
|
5000
|
500 mg;
1 gram |
|
MPEG-SIL
|
mPEG-Silane
|
5000
|
1 gram;
5 gram |
|
SIL-PEG-SIL
|
Silane-PEG-Silane
|
3400
|
1 gram
|
|
MPEG-SH
|
mPEG-Thiol
|
2000;5000;10K;20K;30K
|
1 gram;
5 gram |
|
SH-PEG-SH
|
Thiol-PEG-Thiol
|
3400
|
1 gram;
5 gram |
|
货号
|
产品
|
分子量
|
规格
|
|
MPEG-ACRL
|
mPEG-Acrylate
|
1000;2000;10K
|
1 gram
|
|
ACRL-PEG-ACRL
|
Acrylate-PEG-Acrylate
|
1000
|
1 gram
|
|
ACRL-PEG-MAL
|
Acrylate-PEG-Maleimide
|
3400;5000
|
500 mg;
1 gram |
|
ACRL-PEG-SVA
|
Acrylate-PEG-SVA
|
2000;5000;8000
|
500 mg;
1 gram |
|
4arm-PEG-ACRL
|
4arm-PEG-ACRL
|
20K
|
1 gram;
5 gram |
|
MPEG-pALD
|
mPEG-Propionaldehyde
|
1000;2000;5000;30K
|
1 gram
|
|
bALD-PEG-bALD
|
ButyrAldehyde-PEG-ButyrAldehyde
|
10K;20K;35K
|
1 gram;
5 gram |
|
bALD-PEG-SVA
|
ButyrAldehyde-PEG-SVA
|
2000
|
1 gram
|
|
bALD-PEG-VA
|
ButyrAldehyde-PEG-Valeric Acid
|
3400
|
1 gram;
5 gram |
|
MPEG-NH2
|
mPEG-Amine
|
550;1000
|
1 gram;
5 gram |
|
NH2-PEG-NH2
|
Amine-PEG-Amine
|
550;1K;35K
|
1 gram
|
|
NH2-PEG-CM
|
NH2-PEG-CM
|
2000;3400;5000
|
500 mg;
1 gram |
|
NH2-PEG-SH
|
NH2-PEG-Thiol
|
1000;10K
|
500 mg;
1 gram |
|
Biotin-PEG-NH2
|
Biotin-PEG-NH2
|
550;2000;5000
|
500 mg;
1 gram |
|
Biotin-PEG-Amine
|
Biotin-PEG-NH2
|
10K
|
1 gram
|
|
Biotin-PEG-NH2
|
Biotin-PEG-NH2
|
10K
|
100 mg
500 mg |
|
DSPE-PEG-NH2
|
DSPE-PEG-NH2
|
2000;5000
|
1 gram;
500 mg |
|
FMOC-NH-PEG-NH2-TFA
|
FMOC-NH-PEG-NH2*TFA salt
|
1K;5K
|
1 gram;
5 gram |
|
联系电话：18018625233(同微信) QQ:2303607288
|
|||
|
HO-PEG-NH2
|
HO-PEG-NH2
|
1000;2000;5000;35K
|
500 mg;
1 gram |
|
BOC-PEG-NH2
|
t-Butoxycarbonyl-Amine-PEG-Amine
|
1000
|
1 gram;
5 gram |
|
BOC-NH-PEG-NH2
|
BOC-NH-PEG-Amine
|
5K
|
500 mg;
1 gram; 5 gram |
|
4arm-PEG-NH2
|
4arm-PEG-NH2
|
20K
|
1 gram;
5 gram |
|
Biotin-PEG-Biotin
|
Biotin-PEG-Biotin
|
3400
|
1 gram
|
|
Biotin-PEG-DSPE
|
Biotin-PEG-DSPE
|
1000;2000
|
500 mg;
1 gram |
|
Biotin-PEG-MAL
|
Biotin-PEG-Maleimide
|
5000;5K;10K
|
1 gram
|
|
Biotin-PEG-SC
|
Biotin-PEG-SC
|
2000
|
100 mg
500 mg; 1 gram |
|
Biotin-PEG-SVA
|
Biotin-PEG-SVA
|
10K;20K
|
100 mg
500 mg; 1 gram |
|
Biotin-PEG-SIL
|
Biotin-PEG-Silane
|
5K
|
1 gram
|
MPEG-CM
|
mPEG-Carboxymethyl
|
2000;5000;10K;20K
|
1 gram;
5 gram |
|
|
ASA-PEG-ASA
|
Amino Succinic Acid-PEG-Amino Succinic Acid
|
20K
|
1 gram
|
|
CM-PEG-CM
|
Carboxymethyl-PEG-Carboxymethyl
|
1000;2000;5000
|
1 gram;
5 gram |
|
CM-PEG-DSPE
|
Carboxymethyl-PEG-DSPE
|
2000;5000
|
500 mg
|
|
CM-PEG-SCM
|
Carboxymethyl-PEG-Succinimidyl Carboxymethyl
|
35K
|
1 gram;
5 gram |
|
CM-PEG-SH
|
Carboxymethyl-PEG-Thiol
|
2000
|
500 mg;
1 gram |
|
FMOC-NH-PEG-CM
|
FMOC-NH-PEG-CM
|
3400;5000
|
500 mg;
1 gram |
|
HO-PEG-CM
|
HO-PEG-CM
|
2000;5000
|
500 mg;
1 gram |
|
SC-PEG-CM
|
SC-PEG-CM
|
3400;5000
|
500 mg;
1 gram |
|
4arm-PEG-ASA
|
4arm-PEG-ASA
|
20K
|
1 gram
|
|
联系电话：18018625233(同微信) QQ:2303607288
|
|||
|
MPEG-EPOX
|
mPEG-Epoxide
|
2000;5000
|
1 gram
|
|
EPOX-PEG-EPOX
|
Epoxide-PEG-Epoxide
|
2K;5K
|
1 gram;
5 gram |
|
4arm-PEG-EPOX
|
4arm-PEG-Epoxide
|
10K;20K
|
1 gram;
5 gram |
|
MPEG-SG
|
mPEG-Succinimidyl Glutarate
|
2000;10K;20K;30K
|
1 gram;
5 gram |
|
MPEG-SPA
|
mPEG-SPA
|
550;1000
|
1 gram;
5 gram |
|
MPEG-SS
|
mPEG-Succinimidyl Succinate
|
30K
|
1 gram;
5 gram |
|
SAS-PEG-SAS
|
SAS-PEG-SAS
|
2000
|
1 gram;
5 gram |
|
SG-PEG-SG
|
SG-PEG-SG
|
5K;10K
|
1 gram;
5 gram |
|
SS-PEG-SS
|
SS-PEG-SS
|
2000
|
1 gram
|
|
SVA-PEG-SVA
|
SVA-PEG-SVA
|
1000;5K
|
1 gram;
5 gram |
|
Biotin-PEG-SC
|
Biotin-PEG-SC
|
3400
|
100 mg
500 mg; 1 gram |
|
Biotin-PEG-SVA
|
Biotin-PEG-SVA
|
3400
|
100 mg
500 mg; 1 gram |
FMOC-NH-PEG-SC
|
FMOC-NH-PEG-SC
|
2000
|
500 mg;
1 gram |
|
|
FMOC-NH-PEG-SVA
|
FMOC-NH-PEG-SVA
|
5K
|
500 mg;
1 gram |
|
MAL-PEG-SVA
|
Maleimide-PEG-Succinimidyl Valerate
|
5000;10K;20K
|
100 mg
500 mg |
|
OPSS-PEG-SVA
|
OPSS-PEG-SVA
|
3400
|
500 mg;
1 gram |
|
BOC-NH-PEG-SC
|
BOC-NH-PEG-SC
|
2K;5000;5K;5000
|
500 mg;
1 gram |
|
BOC-NH-PEG-SVA
|
BOC-NH-PEG-SVA
|
2000;5K
|
500 mg;
1 gram |
|
4arm-PEG-SAS
|
4arm-PEG-SAS
|
20K
|
1 gram
|
|
4arm-PEG-SC
|
4arm-PEG-SC
|
20K
|
1 gram
|
|
4arm-PEG-SG
|
4arm-PEG-SG
|
20K
|
1 gram;
5 gram |
|
MPEG-HZ
|
mPEG-Hydrazide
|
2000;5000;10K;20K
|
1 gram
|
|
HZ-PEG-HZ
|
Hydrazide-PEG-Hydrazide
|
2000;3400;5000
|
1 gram
|
|
FMOC-NH-PEG-OH
|
FMOC-NH-PEG-OH
|
5000
|
1 gram;
5 gram |
|
HO-PEG-NH2
|
HO-PEG-NH2
|
20K
|
500 mg;
1 gram |
|
HO-PEG-MAL
|
HO-PEG-MAL
|
2000
|
500 mg;
1 gram |
|
mPEG-MAL
|
mPEG-Maleimide
|
1000
|
1 gram
|
|
MAL-PEG-MAL
|
Maleimide-PEG-Maleimide
|
2K;5K;10K
|
1 gram
|
|
DSPE-PEG-MAL
|
DSPE-PEG-Maleimide
|
2000
|
500 mg;
1 gram |
|
HO-PEG-MAL
|
HO-PEG-MAL
|
5000
|
1 gram
|
4arm-PEG-MAL
|
4arm-PEG-MAL
|
20K
|
1 gram;
5 gram |
|
|
4arm-PEG-SH
|
4arm-PEG-Thiol
|
20K
|
1 gram;
5 gram |
|
mPEG-NPC
|
mPEG-Nitrophenyl Carbonate
|
1000
|
1 gram
|
|
NPC-PEG-NPC
|
NPC-PEG-NPC
|
2000
|
1 gram
|
|
BOC-NH-PEG-NPC
|
BOC-NH-PEG-NPC
|
5000
|
500 mg;
1 gram |
|
MPEG-OPSS
|
mPEG-Orthopyridyl Disulfide
|
2000;10K;20K;30K
|
1 gram
|
|
OPSS-PEG-OPSS
|
OPSS-PEG-OPSS
|
2000;3400
|
1 gram
|
|
MPEG-DSPE
|
mPEG-DSPE
|
2000
|
1 gram
|
|
FMOC-NH-PEG-OH
|
FMOC-NH-PEG-OH
|
2000
|
1 gram
|
|
BOC-NH-PEG-NH2
|
BOC-NH-PEG-Amine
|
2000
|
500 mg;
1 gram; 5 gram |
|
MPEG-SIL
|
mPEG-Silane
|
1000;2000;10K;20K;30K
|
1 gram
|
|
MPEG-SH
|
mPEG-Thiol
|
1000
|
1 gram
|
|
SH-PEG-SH
|
Thiol-PEG-Thiol
|
5K;10K;1000
|
1 gram;
5 gram |
|
MPEG-SH
|
mPEG-Thiol
|
1000
|
1 gram
|
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