人参皂苷Ro | CAS:34367-04-9

 

IC50 Value & Target: 259.4 μm (for 5α-reductase ) 

In Vitro: Ginsenoside Ro exhibited suppressive activities on reactive oxygen species and matrix metalloproteinase-2 elevation in UV-B-irradiated fibroblasts. Ginsenoside Ro could overcome the reduction of the total glutathione contents in UV-B-irradiated fibroblasts. In IL-1β-induced rat chondrocytes, ginsenoside Ro exerted anti-apoptosis and anti-inflammation. Ro could improve IL-1β-induced chondrocytes viability. Ginsenoside Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-xL and PCNA. Ginsenoside Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ginsenoside Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2. Moreover, ginsenoside Ro inhibited NF-κB p65 phosphorylation induced by IL-1β [2]. 

In Vivo: Topical administration of ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shavin in the testosterone-treated C57BL/6 mice. Ginsenoside Ro showed inhibitory activity against 5αR with IC(50) value of 259.4 μm [3].